What Is Lamin Protein

The extracellular matrix ecm lies outside of cells and provides support and attachment for cells inside organs along with many other functions.

What is lamin protein.

Lamins have elastic and mechanosensitive properties and can alter gene regulation in a feedback response to mechanical cues. Laminin is defined by the webster medical dictionary as a glycoprotein that is a component of connective tissue basement membrane and that promotes cell adhesion in other words looking at laminin as a kind of glue isn t far from the truth. These proteins are made up of a nearly identical sequence of protein building blocks amino acids. Lamins are present in all animals but are not found in microorganisms.

There are several different laminins. Laminins are high molecular weight 400 to 900 kda proteins of the extracellular matrix they are a major component of the basal lamina one of the layers of the basement membrane a protein network foundation for most cells and organs the laminins are an important and biologically active part of the basal lamina influencing cell differentiation migration and adhesion. Lamins line the inside of the nuclear membrane where they provide a platform for the binding of proteins and chromatin and confer mechanical stability. The two major proteins produced from this gene lamin a and lamin c are made in most of the body s cells.

Lamins also known as nuclear lamins are fibrous proteins in type v intermediate filaments providing structural function and transcriptional regulation in the cell nucleus. Laminin has arms that associate with other laminin molecules to form sheets and bind to cells. Nuclear lamins interact with inner nuclear membrane proteins to form the nuclear lamina on the interior of the nuclear envelope.